Depulpin

Vyráběný přípravek k devitalizaci je Toxavit (http://www.legeartis.de/produkte/endodontie/toxavit.html). Ten obsahuje jako účinné látky paraformaldehyd (46%), lidokain hydrochlorid (37%) a metakresol (4,5%), mezi pomocnými látkami pak je eugenol a glycerol a ještě složku, kterou bych asi přeložila jako uhlíková vlákna (nejsem si jistá). Tento přípravek ale u nás taky není registrovaný (stejně jako Depulpin). Můžete zkusit mimořádný dovoz.
 
K přípravě v lékárně – žádné vlastní zkušenosti s tím nemáme a nenašla jsem nic ani v publikaci Magistraliter receptura ve stomatologii ani v německém receptáři NRF/SR. Našla jsem, že by složení paraformaldehydové pasty mělo být v Japonském lékopise, ale ten nemám k dispozici. V každém případě bude třeba získat paraformaldehyd s atestem – protože není v českém lékopise, tak nechat vyzkoušet podle jiného lékopisu (japonského?).
 
Pokud někdo má zkušenosti s přípravou a nebo zná jiný dostupný vyráběný přípravek a napíše na komoru, rádi to tu zveřejníme.
 
Mgr. Hana Šnajdrová

PS: díky pomoci SUKLu mám články z  Japonského lékopisu – Dental paraformaldehyde paste i Paraformaldehyd. Příprava pasty bude jednoduchá, pokud se Vám podaří sehnat ten paraformaldehyd s atestem.
 
Dental Paraformaldehyde Paste
歯科用パラホルムパスタ
Method of preparation
Paraformaldehyde, finely powdered 35 g
Procaine Hydrochloride, finely
powdered 35 g
Hydrous Lanolin a sufficient quantity
To make 100 g
Prepare as directed under Ointments, with the above in-
gredients.
Description Dental Paraformaldehyde Paste is yellowish
white in color. It has a characteristic odor.
Identification (1) To 0.15 g of Dental Paraformaldehyde
Paste add 20 mL of diethyl ether and 20 mL of 0.5 mol/L
sodium hydroxide TS, shake well, separate the water layer,
and dilute with water to make 100 mL. To 1 mL of this solu-
tion add 10 mL of acetylacetone TS, and heat on a water
bath for 10 minutes: a yellow color is produced (paraformal-
dehyde).
(2) To the diethyl ether layer obtained in (1) add 5 mL of
dilute hydrochloric acid and 20 mL of water, shake well, and
separate the water layer: the solution responds to Qualitative
Tests <1.09> for primary aromatic amines (procaine hydro-
chloride).
(3) To 0.15 g of Dental Paraformaldehyde Paste add 25
mL of diethyl ether and 25 mL of water, shake, separate the
water layer, filter, and use the filtrate as the sample solution.
Seperately, dissolve 0.01 g of procaine hydrochloride in 5
mL of water, and use this solution as standard solution. Per-
form the test with these solutions as directed under Thin-
layer Chromatography <2.03>. Spot 5 mL each of the sample
solution and standard solution on a plate of silica gel with
fluorescent indicator for thin-layer chromatography. Devel-
op the plate with a mixture of ethyl acetate, ethanol (99.5)
and ammonia solution (28) (50:5:1) to a distance of about 10
cm, and air-dry the plate. Examine under ultraviolet light
(main wavelength: 254 nm): spots from the sample solution
and standard solution show the same Rf value.
Containers and storage Containers.Tight containers.
 
 
Paraformaldehyde
パラホルムアルデヒド
(CH2O)n
Poly(oxymethylene)
[30525-89-4]
Paraformaldehyde contains not less than 95.0z of
CH2O: 30.03.
Description Paraformaldehyde occurs as a white powder.
It has a slight odor of formaldehyde, but a very strong
irritating odor is perceptible when it is heated.
It is practically insoluble in water, in ethanol (95) and in
diethyl ether.
It dissolves in hot water, in hot dilute hydrochloric acid, in
JP XVI Official Monographs / Dental Paraformaldehyde Paste 1215
sodium hydroxide TS and in ammonia TS.
It sublimes at about 1009C.
Identification (1) Dissolve 0.1 g of Paraformaldehyde in
5 mL of ammonia TS, add 5 mL of silver nitrate TS, shake,
and add 3 mL of a solution of sodium hydroxide (1 in 10): a
mirror of metallic silver is immediately formed on the sides
of the container.
(2) Add a solution of 0.04 g of salicylic acid in 5 mL of
sulfuric acid to 0.02 g of Paraformaldehyde, and warm
slowly: a persistent, dark red color is produced.
Purity (1) Clarity and color of solution.Dissolve 0.20 g
of Paraformaldehyde in 10 mL of ammonia TS: the solution
is clear and colorless.
(2) Acidity or alkalinity.To 0.5 g of Paraformaldehyde
add 10 mL of water, shake vigorously for 1 minute, and
filter: the filtrate is neutral.
(3) Chloride <1.03>.Dissolve 1.5 g of Paraformalde-
hyde in 75 mL of water and 7.5 mL of sodium carbonate TS,
evaporate on a water bath to dryness, and ignite at about
5009C. Dissolve the residue in 15 mL of water, filter, if nec-
essary, neutralize with diluted nitric acid (3 in 10), and add 6
mL of dilute nitric acid and water to make 50 mL. Perform
the test using this solution as the test solution. Prepare the
control solution as follows: to 0.25 mL of 0.01 mol/L hydro-
chloric acid VS add 7.5 mL of sodium carbonate TS, a
volume of diluted nitric acid (3 in 10) required for neutraliza-
tion of the sample, 6 mL of dilute nitric acid and water to
make 50 mL (not more than 0.006z).
(4) Sulfate <1.14>.Dissolve 1.5 g of Paraformaldehyde
in 45 mL of water and 4.5 mL of sodium carbonate TS,
evaporate on a water bath to dryness, and ignite at abut
5009C. Dissolve the residue in 15 mL of water, filter, if nec-
essary, neutralize the diluted hydrochloric acid (3 in 5), and
boil for 5 minutes. After cooling, add 1 mL of dilute hydro-
chloric acid and water to make 50 mL. Perform the test
using this solution as the test solution. Prepare the control
solution as follows: to 4.5 mL of sodium carbonate TS add
an equal volume of diluted hydrochloric acid (3 in 5) for the
neutralization of the sample and 15 mL of water, and boil
for 5 minutes. After cooling, add 0.35 mL of 0.005 mol/L
sulfuric acid VS, 1 mL of dilute hydrochloric acid and water
to make 50 mL (not more than 0.011z).
Residue on ignition <2.44> Not more than 0.1z (1 g).
Assay Dissolve about 50 mg of Paraformaldehyde, accu-
rately weighed, in 10 mL of potassium hydroxide TS in an
iodine flask. Add 40 mL of water and an exactly measured
50 mL of 0.05 mol/L iodine VS, stopper, and allow to stand
for 5 minutes. Then add 5 mL of dilute hydrochloric acid,
stopper immediately, allow to stand for 15 minutes, and
titrate <2.50> the excess iodine with 0.1 mol/L sodium thio-
sulfate VS (indicator: 1 mL of starch TS). Perform a blank
determination.
Each mL of 0.05 mol/L iodine VS＝ 1.501 mg of CH2O
Containers and storage Containers.Tight containers.